Carbonylation is a hallmark of oxidative stress induced by lipid peroxidation products, 4-hydroxy-2-nonenal and 4-hydroxy-2- hexenal, on insulin signalling in L6 myoblasts.

• Main Author: Chionh, Yok Hian.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/18971
• Institution: Nanyang Technological University

Peripheral insulin resistance is one of the defining characteristics of type 2 diabetes - a metabolic disorder commonly associated with oxidative stress. Obesity and exposure to atmospheric oxidants, such as ozone gas, induces oxidative stress which increases lipid peroxidation. However, it is still...