MYCOBACTERIAL DORMANCY AND PERSISTENCE: MOLECULAR MECHANISMS CONTROLLING STRESS RESPONSE, SURVIVAL AND ADAPTATION

by CHIONH YOK HIAN
Published 2015

Carbonylation is a hallmark of oxidative stress induced by lipid peroxidation products, 4-hydroxy-2-nonenal and 4-hydroxy-2- hexenal, on insulin signalling in L6 myoblasts.

by Chionh, Yok Hian.
Published 2009

tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum

by Dedon, Peter C., Preiser, Peter Rainer, Ng, Chee Sheng, Sinha, Ameya, Aniweh, Yaw, Nah, Qianhui, Babu, Indrakanti Ramesh, Gu, Chen, Chionh, Yok Hian
Published 2019

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans

by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan
Published 2018

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

by Zhong, Wenhe, Cui, Liang, Goh, Boon Chong, Cai, Qixu, Ho, Peiying, Chionh, Yok Hian, Yuan, Meng, Sahili, Abbas El, Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Lescar, Julien, Dedon, Peter Christian
Published 2018

Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in mycobacterium tuberculosis

by Zhong, Wenhe, Guo, Jingjing, Cui, Liang, Chionh, Yok Hian, Li, Kuohan, El Sahili, Abbas, Cai, Qixu, Yuan, Meng, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Mu, Yuguang, Lescar, Julien, Dedon, Peter C.
Published 2021

Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope

by Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram
Published 2020

Thienopyrimidinone derivatives that inhibit bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) by restructuring the active site with a tyrosine-flipping mechanism

by Zhong, Wenhe, Pasunooti, Kalyan Kumar, Balamkundu, Seetharamsing, Wong, Yee Hwa, Nah, Qianhui, Gadi, Vinod, Gnanakalai, Shanmugavel, Chionh, Yok Hian, McBee, Megan E., Gopal, Pooja, Lim, Siau Hoi, Olivier, Nelson, Buurman, Ed T., Dick, Thomas, Liu, Chuan Fa, Lescar, Julien, Dedon, Peter C.
Published 2021

Targeting the bacterial epitranscriptome for antibiotic development : discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors

by Zhong, Wenhe, Koay, Ann, Ngo, Anna, Li, Yan, Nah, Qianhui, Wong, Yee Hwa, Chionh, Yok Hian, Ng, Hui Qi, Koh-Stenta, Xiaoying, Poulsen, Anders, Foo, Klement, McBee, Megan, Choong, Meng Ling, El Sahili, Abbas, Kang, Congbao, Matter, Alex, Lescar, Julien, Hill, Jeffrey, Dedon, Peter
Published 2021

A multidimensional platform for the purification of non-coding RNA species

by Ho, Chia-Hua, Pruksakorn, Dumnoensun, Babu, I. Ramesh, Ng, Chee Sheng, Hia, Fabian, Chionh, Yok Hian, McBee, Megan E., Su, Dan, Pang, Yan Ling Joy, Gu, Chen, Dong, Hongping, Prestwich, Erin G., Shi, Pei-Yong, Preiser, Peter Rainer, Alonso, Sylvie, Dedon, Peter C.
Published 2013