Synthesis of natural products by intramolecular Michael addition

• Main Author: Song, Ping
• Other Authors: Roderick Wayland Bates
• Format: Theses and Dissertations
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: https://hdl.handle.net/10356/22909
• Institution: Nanyang Technological University

The intramolecular hetero-Michael addition is one of the most convergent strategies for the synthesis of six membered heterocyclic rings from α,β-unsaturated carbonyl compounds. However, the selection of suitable precursors for the Michael addition so as to provide the efficient stereocontrol is still a challenging issue and seldom reported in the literature. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A.