Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.

An efficient method for allenation/cycloisomerization reaction of propargylic alcohols with amides in the presence of Yb(OTf)3 (5 mol %) at 100oC to afford oxazoles in moderate to excellent yields is reported herein. The method features ease of starting material preparation, use of a low cost and...

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Main Author:	Teo, Wan Teng.
Other Authors:	Philip Wai Hong Chan
Format:	Final Year Project
Language:	English
Published:	2010
Subjects:	DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
Online Access:	http://hdl.handle.net/10356/39686
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-39686
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spelling	sg-ntu-dr.10356-396862023-02-28T23:12:20Z Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives. Teo, Wan Teng. Philip Wai Hong Chan School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds An efficient method for allenation/cycloisomerization reaction of propargylic alcohols with amides in the presence of Yb(OTf)3 (5 mol %) at 100oC to afford oxazoles in moderate to excellent yields is reported herein. The method features ease of starting material preparation, use of a low cost and ecologically benign Lewis acid as catalyst under operationally simplistic conditions. Bachelor of Science in Chemistry and Biological Chemistry 2010-06-03T00:48:21Z 2010-06-03T00:48:21Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39686 en 40 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
spellingShingle	DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds Teo, Wan Teng. Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
description	An efficient method for allenation/cycloisomerization reaction of propargylic alcohols with amides in the presence of Yb(OTf)3 (5 mol %) at 100oC to afford oxazoles in moderate to excellent yields is reported herein. The method features ease of starting material preparation, use of a low cost and ecologically benign Lewis acid as catalyst under operationally simplistic conditions.
author2	Philip Wai Hong Chan
author_facet	Philip Wai Hong Chan Teo, Wan Teng.
format	Final Year Project
author	Teo, Wan Teng.
author_sort	Teo, Wan Teng.
title	Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
title_short	Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
title_full	Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
title_fullStr	Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
title_full_unstemmed	Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
title_sort	yb(otf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
publishDate	2010
url	http://hdl.handle.net/10356/39686
_version_	1759853808803905536

Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.

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