Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.

• Main Author: Teo, Wan Teng.
• Other Authors: Philip Wai Hong Chan
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: http://hdl.handle.net/10356/39686
• Institution: Nanyang Technological University

An efficient method for allenation/cycloisomerization reaction of propargylic alcohols with amides in the presence of Yb(OTf)3 (5 mol %) at 100oC to afford oxazoles in moderate to excellent yields is reported herein. The method features ease of starting material preparation, use of a low cost and...