Fe(III)- and Au(I)-catalyzed cyclization of arene-alkynes.

• Main Author: Gao, Zhi Ming.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: http://hdl.handle.net/10356/39870
• Institution: Nanyang Technological University

In this research report, Fe(III)- and Au(I)-catalyzed cyclizations of arene-alkynes were investigated. Au(I) catalyst has shown to be of very efficient catalytic activity for intramolecular hydroarylations of arene-alkynes with promising yields at mild conditions whether the alkyne is substituted by electron-withdrawing or electron-donating group. While Fe(III) was shown to be sensitive to the substitute on the alkyne moiety, electron-withdrawing group substituted alkynes did not proceed to cyclized products, but for the electron-donating group substituted arene-alkynes, Fe(III) catalyst showed as high efficiency as Au(I) catalyst.