Synthesis of substituted pyrrolo- and indolo-quinoxalines via the gold(i)-catalyzed tandem hydroamination-hydroarylation of pyrrole- and indole-substituted anilines with aromatic terminal alkynes.

• المؤلف الرئيسي: Koh, Chii Boon.
• مؤلفون آخرون: Philip Wai Hong Chan
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2010
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/40106
• المؤسسة: Nanyang Technological University

A concise, asymmetric synthesis of substituted 3-pyrrolines from the corresponding amino-homoallylic alcohols derived from amino acids is described. The key step is an intramolecular hydroamination reaction catalyzed by copper(II) triflate. The 3-pyrroline products were obtained in moderate to good...