Synthesis of substituted pyrrolo- and indolo-quinoxalines via the gold(i)-catalyzed tandem hydroamination-hydroarylation of pyrrole- and indole-substituted anilines with aromatic terminal alkynes.

• 主要作者: Koh, Chii Boon.
• 其他作者: Philip Wai Hong Chan
• 格式: Final Year Project
• 語言: English
• 出版: 2010
• 主題: DRNTU::Science::Chemistry::Organic chemistry
• 在線閱讀: http://hdl.handle.net/10356/40106
• 機構: Nanyang Technological University

A concise, asymmetric synthesis of substituted 3-pyrrolines from the corresponding amino-homoallylic alcohols derived from amino acids is described. The key step is an intramolecular hydroamination reaction catalyzed by copper(II) triflate. The 3-pyrroline products were obtained in moderate to good...