Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.

Malaria is a global infectious disease cause by a parasite of the Plasmodium genus. Anti-malarial drug resistance has been rising and there is an urgent need to understand the mechanisms behind drug resistance. Copy Number Variations (CNVs) have been shown to contribute to genetic variations and ass...

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Main Author: Guo, Weiliang.
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2012
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Online Access:http://hdl.handle.net/10356/49291
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-492912023-02-28T18:02:19Z Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance. Guo, Weiliang. School of Biological Sciences Zbynek Bozdech DRNTU::Science::Biological sciences::Microbiology::Drug Resistance Malaria is a global infectious disease cause by a parasite of the Plasmodium genus. Anti-malarial drug resistance has been rising and there is an urgent need to understand the mechanisms behind drug resistance. Copy Number Variations (CNVs) have been shown to contribute to genetic variations and associated to resistance in various anti-malaria drugs. Hence, we aim to study the CNVs of the deadliest strain of malaria parasite, Plasmodium falciparum, in South East Asia (Thailand, Cambodia and Laos) and to identify if there is any association between CNVs and artemisinin resistance. CNVs were shown to be enriched in sub-telomeric regions of P.falciparum and can arise when the parasites are subjected to selection pressure. A number of CNV genes were also identified to be associating to artemisinin resistance. Some of these may have involvement in various artemisinin resistance mechanisms previously reported. These suggested that artemisinin resistance phenotype in P.falciparum may be a multifactorial trait which involves multiple pathways. Furthermore, CNV profile showing several populations of the parasite with different sensitivity to artemisinin may allow the development of tools for estimation of artemisinin sensitivity of the parasite. This can greatly improve clinical diagnostic of malaria. Bachelor of Science in Biological Sciences 2012-05-17T01:11:29Z 2012-05-17T01:11:29Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49291 en Nanyang Technological University 37 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
spellingShingle DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
Guo, Weiliang.
Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
description Malaria is a global infectious disease cause by a parasite of the Plasmodium genus. Anti-malarial drug resistance has been rising and there is an urgent need to understand the mechanisms behind drug resistance. Copy Number Variations (CNVs) have been shown to contribute to genetic variations and associated to resistance in various anti-malaria drugs. Hence, we aim to study the CNVs of the deadliest strain of malaria parasite, Plasmodium falciparum, in South East Asia (Thailand, Cambodia and Laos) and to identify if there is any association between CNVs and artemisinin resistance. CNVs were shown to be enriched in sub-telomeric regions of P.falciparum and can arise when the parasites are subjected to selection pressure. A number of CNV genes were also identified to be associating to artemisinin resistance. Some of these may have involvement in various artemisinin resistance mechanisms previously reported. These suggested that artemisinin resistance phenotype in P.falciparum may be a multifactorial trait which involves multiple pathways. Furthermore, CNV profile showing several populations of the parasite with different sensitivity to artemisinin may allow the development of tools for estimation of artemisinin sensitivity of the parasite. This can greatly improve clinical diagnostic of malaria.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Guo, Weiliang.
format Final Year Project
author Guo, Weiliang.
author_sort Guo, Weiliang.
title Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
title_short Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
title_full Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
title_fullStr Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
title_full_unstemmed Investigation of Copy Number Variations (CNVs) in South-East Asia (SEA) Plasmodium falciparum isolates and association with artemisinin resistance.
title_sort investigation of copy number variations (cnvs) in south-east asia (sea) plasmodium falciparum isolates and association with artemisinin resistance.
publishDate 2012
url http://hdl.handle.net/10356/49291
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