Generation of female fibroblast cell lines in which Xist is conditionally and allele-specifically deleted from the inactive X chromosome.

Dosage compensation is accomplished by X chromosome inactivation (XCI) in female cells of placental mammals. The silencing of either the paternal or the maternal X chromosome ensures the equal expression of X-linked genes in males and females. Xist is a critical gene involved in regulating XCI. The...

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Bibliographic Details
Main Author: Chen, Beibei.
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10356/50882
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Institution: Nanyang Technological University
Language: English