Physiological properties of cerebellar circuits in a mouse model for Angelman Syndrome and modulation of inhibitory transmission by NMDA receptor activation in the mouse hippocampus
UBE3A encodes the ubiquitin ligase E6-AP and the point mutation of this gene causes severe neurological disorder called Angelman Syndrome (AS) in a young child. To elucidate the molecular basis of AS pathogenesis and promote the design of rational therapies for AS patient, an Ube3a null mutation mou...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/51022 |
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| Institution: | Nanyang Technological University |
| Language: | English |