Physiological properties of cerebellar circuits in a mouse model for Angelman Syndrome and modulation of inhibitory transmission by NMDA receptor activation in the mouse hippocampus

• Main Author: Xue, Jiu Gang
• Other Authors: Law Sai-Kit, Alex
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/51022
• Institution: Nanyang Technological University

UBE3A encodes the ubiquitin ligase E6-AP and the point mutation of this gene causes severe neurological disorder called Angelman Syndrome (AS) in a young child. To elucidate the molecular basis of AS pathogenesis and promote the design of rational therapies for AS patient, an Ube3a null mutation mou...