Physiological properties of cerebellar circuits in a mouse model for Angelman Syndrome and modulation of inhibitory transmission by NMDA receptor activation in the mouse hippocampus

• 主要作者: Xue, Jiu Gang
• 其他作者: Law Sai-Kit, Alex
• 格式: Theses and Dissertations
• 語言: English
• 出版: 2013
• 主題: DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/51022

UBE3A encodes the ubiquitin ligase E6-AP and the point mutation of this gene causes severe neurological disorder called Angelman Syndrome (AS) in a young child. To elucidate the molecular basis of AS pathogenesis and promote the design of rational therapies for AS patient, an Ube3a null mutation mou...