Analyzing the roles of human U1 snRNA variants in pre-mRNA processing.

• المؤلف الرئيسي: Goh, Eling.
• مؤلفون آخرون: Fabrizio Galli
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences::Genetics
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/52293
• المؤسسة: Nanyang Technological University

Splicing and polyadenylation are two essential steps in pre-mRNA processing. During splicing, U1 snRNP binds to a diversity of 5’ splice sites (5’ss) with its 5’ end. However, there remains a number of 5’ss that could not be bound optimally by the U1 snRNP. Very recently, U1 snRNA class I pseudogene...