Knockdown effects of CHIP and UCH-L1 on chaperone-mediated autophagy.

• Main Author: Tso, Rachel Ai Fang.
• Other Authors: Wong, Esther
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/52700
• Institution: Nanyang Technological University

Chaperone-mediated autophagy (CMA) is a selective form of autophagy which degrades cytosolic proteins bearing a CMA-targeting motif. CMA is carried out by chaperone proteins and aberrant CMA function has been implicated in disease. Its physiological regulation is not well understood, which is import...