A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.

A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.

Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In...

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Main Author: Elavazhagan Murugan.
Other Authors: Liang Zhao-Xun
Format: Theses and Dissertations
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/53489
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-534892023-02-28T18:32:39Z A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. Elavazhagan Murugan. Liang Zhao-Xun School of Biological Sciences DRNTU::Science::Biological sciences Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In this project, we examine the structures and functions of the domains of CalE8, to demarcate the domains of the the iterative PKS from the biosynthetic pathway of the 10-membered enediyne calicheamicin in Micromonospora echinospora spp. DOCTOR OF PHILOSOPHY (SBS) 2013-06-04T04:44:44Z 2013-06-04T04:44:44Z 2012 2012 Thesis Elavazhagan Murugan. (2012). A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/53489 10.32657/10356/53489 en 181 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
spellingShingle DRNTU::Science::Biological sciences
Elavazhagan Murugan.
A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
description Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In this project, we examine the structures and functions of the domains of CalE8, to demarcate the domains of the the iterative PKS from the biosynthetic pathway of the 10-membered enediyne calicheamicin in Micromonospora echinospora spp.
author2 Liang Zhao-Xun
author_facet Liang Zhao-Xun
Elavazhagan Murugan.
format Theses and Dissertations
author Elavazhagan Murugan.
author_sort Elavazhagan Murugan.
title A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
title_short A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
title_full A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
title_fullStr A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
title_full_unstemmed A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.
title_sort study of the functional domains of the type i iterative polyketide synthase cale8 in calicheamicin biosynthesis.
publishDate 2013
url https://hdl.handle.net/10356/53489
_version_ 1759853441111293952

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