Characterization of molecular differences between WASP and N-WASP and characterization of mutations causing Wiskott-Aldrich syndrome

• Main Author: Neeraj Jain
• Other Authors: Thirumaran s/o Thanabalu
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: https://hdl.handle.net/10356/54852
• Institution: Nanyang Technological University

Wiskott-aldrich Syndrome is caused by mutation in gene encodes WASP. WASP and its homologue N-WASP regulate actin cytoskeleton reorganization, share more than 50% sequence identity. Knocking down of WASP expression impaired Jurkat T-cells chemotaxis towards SDF-1α and increased adhesion to fibronect...