Novel functions of the oncofetal HMGA2 protein in genome stability

• Main Author: Yu, Haojie
• Other Authors: Peter Droge
• Format: Theses and Dissertations
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/55737
• Institution: Nanyang Technological University

The non-histone chromatin factor HMGA2 (High Mobility Group AT-hook 2), which contains three AT-hook motifs as independent DNA binding domains, is normally expressed in ES cells and during embryonic/fetal development. In this study, I investigated its function in protecting the stalled replication f...