Molecular recognition in G-quadruplexes : from G-tetrad formation to protein binding
Under physiological conditions, guanine-rich oligonucleotides may assemble into a four-stranded structure, the G-quadruplex. G-quadruplexes may cause genomic instability in cells, requiring modulation by proteins. As guanine-rich DNA is susceptible to DNA damage, a G-quadruplex with complementary 8-...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/65412 |
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| Institution: | Nanyang Technological University |
| Language: | English |