Molecular recognition in G-quadruplexes : from G-tetrad formation to protein binding

• Main Author: Cheong, Vee Vee
• Other Authors: Phan Anh Tuan
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Biochemistry::Spectroscopy
• Online Access: https://hdl.handle.net/10356/65412
• Institution: Nanyang Technological University

Under physiological conditions, guanine-rich oligonucleotides may assemble into a four-stranded structure, the G-quadruplex. G-quadruplexes may cause genomic instability in cells, requiring modulation by proteins. As guanine-rich DNA is susceptible to DNA damage, a G-quadruplex with complementary 8-...