Native chemical ligation on aspartic acid and its application towards convergent synthesis of homogeneous N-glycoprotein

• Main Author: Chai, Hua
• Other Authors: Liu Chuan Fa
• Format: Theses and Dissertations
• Language: English
• Published: 2016
• Subjects: DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• Online Access: http://hdl.handle.net/10356/66214
• Institution: Nanyang Technological University

Total synthesis of native and functional proteins was almost unachievable back in the early 1990s, but thanks to Prof Kent’s development on native chemical ligation (NCL), chemical protein synthesis has become attainable. The basis of NCL technique is the chemoselective reaction between a peptide th...