A study on X chromosome reactivation using iXist

• المؤلف الرئيسي: Lai, Lan Tian
• مؤلفون آخرون: Zhang Li-Feng
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2017
• الموضوعات: DRNTU::Science::Biological sciences::Genetics
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/72782
• المؤسسة: Nanyang Technological University

Female mammals inactivate one of the two X chromosomes in each somatic cell in order to balance the X-linked gene dosage between females and males (X chromosome inactivation, XCI). This process is mediated by non-coding RNA X inactive specific transcript (Xist). Here, I show that, when embryonic ste...