TGFBIp-associated corneal dystrophy : exploring structure-based drug development strategies for disease prevention and treatment

• المؤلف الرئيسي: Anandalakshmi, Venkatraman
• مؤلفون آخرون: Konstantin Pervushin
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/73264
• المؤسسة: Nanyang Technological University

Corneal Dystrophies are a group of inherited disorders localized to various layers of the cornea that affect corneal transparency and visual acuity. The deposition of insoluble protein materials in the form of extracellular amyloid fibrils or intracellular cysts is pathognomonic. The gene associated...