Knockdown of two ER stress-related genes and their effect on pancreatic beta-cell function

• Main Author: Tan, Patricia Yan Dan
• Other Authors: Yusof Ali
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/74672
• Institution: Nanyang Technological University

ER stress is associated with beta-cell dysfunction in Type 2 diabetes (T2D). A recent study by Dorajoo and colleagues show that several ER stress implicated genes including HSP90B1, DNAJC3, UCHL1 are upregulated in pancreatic islets from Singaporean-Chinese donors. Besides these genes, OLMALINC,...