Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes

Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes

Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes offers an unprecedented access towards novel chiral phosphine motifs. As an expansion of the substrate scope, four substrates that represent oxygen, nitrogen and carbon-bridged bicyclic alkenes were examined fo...

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Bibliographic Details
Main Author: Ong, Yew Jin
Other Authors: Pullarkat A. Sumod
Format: Final Year Project
Language:English
Published: 2018
Subjects:
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
Online Access:http://hdl.handle.net/10356/76198
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Institution: Nanyang Technological University
Language: English
Description
Summary:Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes offers an unprecedented access towards novel chiral phosphine motifs. As an expansion of the substrate scope, four substrates that represent oxygen, nitrogen and carbon-bridged bicyclic alkenes were examined for their compatibility with this approach. Only one enantioenriched product was obtained with a moderate enantiomeric excess of 56%.

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