Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes

Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes

Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes offers an unprecedented access towards novel chiral phosphine motifs. As an expansion of the substrate scope, four substrates that represent oxygen, nitrogen and carbon-bridged bicyclic alkenes were examined fo...

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Main Author: Ong, Yew Jin
Other Authors: Pullarkat A. Sumod
Format: Final Year Project
Language:English
Published: 2018
Subjects:
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
Online Access:http://hdl.handle.net/10356/76198
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-761982023-02-28T23:12:07Z Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes Ong, Yew Jin Pullarkat A. Sumod School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes offers an unprecedented access towards novel chiral phosphine motifs. As an expansion of the substrate scope, four substrates that represent oxygen, nitrogen and carbon-bridged bicyclic alkenes were examined for their compatibility with this approach. Only one enantioenriched product was obtained with a moderate enantiomeric excess of 56%. Bachelor of Science in Chemistry and Biological Chemistry 2018-11-29T01:14:26Z 2018-11-29T01:14:26Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/76198 en 18 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
spellingShingle DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
Ong, Yew Jin
Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
description Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes offers an unprecedented access towards novel chiral phosphine motifs. As an expansion of the substrate scope, four substrates that represent oxygen, nitrogen and carbon-bridged bicyclic alkenes were examined for their compatibility with this approach. Only one enantioenriched product was obtained with a moderate enantiomeric excess of 56%.
author2 Pullarkat A. Sumod
author_facet Pullarkat A. Sumod
Ong, Yew Jin
format Final Year Project
author Ong, Yew Jin
author_sort Ong, Yew Jin
title Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
title_short Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
title_full Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
title_fullStr Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
title_full_unstemmed Palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
title_sort palladacycle-catalyzed asymmetric hydrophosphination of achiral heterobicyclic alkenes
publishDate 2018
url http://hdl.handle.net/10356/76198
_version_ 1759853673976954880

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