Investigating neurodevelopmental defects in MELAS syndrome using neural organoids derived from induced pluripotent stem cells

• المؤلف الرئيسي: Khong, Zi Jian
• مؤلفون آخرون: Ng Shi Yan
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/76217

Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is characterised by many neurological symptoms such as dementia and epilepsy. One of the most prevalent mutation in MELAS is the m.A3243G transition within the MT-TL1 gene, that encodes for mitochondrial tRNAL...