Investigating neurodevelopmental defects in MELAS syndrome using neural organoids derived from induced pluripotent stem cells

• Main Author: Khong, Zi Jian
• Other Authors: Ng Shi Yan
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/76217
• Institution: Nanyang Technological University

Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is characterised by many neurological symptoms such as dementia and epilepsy. One of the most prevalent mutation in MELAS is the m.A3243G transition within the MT-TL1 gene, that encodes for mitochondrial tRNAL...