DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

• المؤلفون الرئيسيون: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Biological Sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81229; http://hdl.handle.net/10220/39206
• المؤسسة: Nanyang Technological University

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...