DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

• Main Authors: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/81229; http://hdl.handle.net/10220/39206
• Institution: Nanyang Technological University

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...