DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...

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Bibliographic Details
Main Authors: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Biological Sciences
Online Access:https://hdl.handle.net/10356/81229
http://hdl.handle.net/10220/39206
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/81229
http://hdl.handle.net/10220/39206

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