Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes

• المؤلفون الرئيسيون: Jia, Yu-Xiang, Chew, Renta Jonathan, Li, Bin-Bin, Zhu, Pengcheng, Li, Yongxin, Pullarkat, Sumod Appukuttan, Tan, Nguan Soon, Leung, Pak-Hing
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Palladium compounds; antineoplastic agent
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81881; http://hdl.handle.net/10220/39745

The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosph...