Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters
Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic este...
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2017
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sg-ntu-dr.10356-822252023-02-28T19:35:35Z Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters Chen, Xingkuan Fong, Jacqueline Zi Mei Xu, Jianfeng Mou, Chengli Lu, Yunpeng Yang, Song Song, Bao-An Chi, Yonggui Robin School of Physical and Mathematical Sciences Carbene-catalyzed reactions Carboxylic esters Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2017-07-31T03:41:08Z 2019-12-06T14:51:12Z 2017-07-31T03:41:08Z 2019-12-06T14:51:12Z 2016 Journal Article Chen, X., Fong, J. Z. M., Xu, J., Mou, C., Lu, Y., Yang, S., et al. (2016). Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters. Journal of the American Chemical Society, 138(23), 7212-7215. 0002-7863 https://hdl.handle.net/10356/82225 http://hdl.handle.net/10220/43496 10.1021/jacs.6b00406 en Journal of the American Chemical Society © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/jacs.6b00406]. 6 p. application/pdf |
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Nanyang Technological University |
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Asia |
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English |
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Carbene-catalyzed reactions Carboxylic esters |
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Carbene-catalyzed reactions Carboxylic esters Chen, Xingkuan Fong, Jacqueline Zi Mei Xu, Jianfeng Mou, Chengli Lu, Yunpeng Yang, Song Song, Bao-An Chi, Yonggui Robin Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| description |
Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Chen, Xingkuan Fong, Jacqueline Zi Mei Xu, Jianfeng Mou, Chengli Lu, Yunpeng Yang, Song Song, Bao-An Chi, Yonggui Robin |
| format |
Article |
| author |
Chen, Xingkuan Fong, Jacqueline Zi Mei Xu, Jianfeng Mou, Chengli Lu, Yunpeng Yang, Song Song, Bao-An Chi, Yonggui Robin |
| author_sort |
Chen, Xingkuan |
| title |
Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| title_short |
Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| title_full |
Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| title_fullStr |
Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| title_full_unstemmed |
Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters |
| title_sort |
carbene-catalyzed dynamic kinetic resolution of carboxylic esters |
| publishDate |
2017 |
| url |
https://hdl.handle.net/10356/82225 http://hdl.handle.net/10220/43496 |
| _version_ |
1759856237420216320 |