Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites

• Main Authors: Brancucci, Nicolas M.B., Bertschi, Nicole L., Zhu, Lei, Niederwieser, Igor, Chin, Wai Hoe, Wampfler, Rahel, Freymond, Céline, Rottmann, Matthias, Felger, Ingrid, Bozdech, Zbynek, Voss, Till S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/82524; http://hdl.handle.net/10220/40061
• Institution: Nanyang Technological University

Clonally variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable gene silen...