Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

• المؤلفون الرئيسيون: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James Pingkwan, Sze, Siu Kwan
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Neurodegenerative disease; Amyloids; Mitochondrial creatine kinase; Deamidation; Brain Proteome; Protein S100A9
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82857; http://hdl.handle.net/10220/40312

Background: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. Results: To characterize amy...