Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

• Main Authors: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James Pingkwan, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Neurodegenerative disease; Amyloids; Mitochondrial creatine kinase; Deamidation; Brain Proteome; Protein S100A9
• Online Access: https://hdl.handle.net/10356/82857; http://hdl.handle.net/10220/40312
• Institution: Nanyang Technological University

Background: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. Results: To characterize amy...