Functional impact of splice isoform diversity in individual cells

• Main Authors: Yap, Karen, Makeyev, Eugene V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Alternative splicing; Isoform co-expression
• Online Access: https://hdl.handle.net/10356/83044; http://hdl.handle.net/10220/42378
• Institution: Nanyang Technological University

Alternative pre-mRNA splicing provides an effective means for expanding coding capacity of eukaryotic genomes. Recent studies suggest that co-expression of different splice isoforms may increase diversity of RNAs and proteins at a single-cell level. A pertinent question in the field is whether such...