Studies on the synthesis of the lasubine alkaloids

Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.

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Main Authors:	Simon, Oliver, Nur Filza Mohamed Aslam, Bates, Roderick Wayland
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2019
Subjects:	Alkaloid Indolizidine Science::Chemistry::Organic chemistry
Online Access:	https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-83262
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spelling	sg-ntu-dr.10356-832622023-02-28T19:32:31Z Studies on the synthesis of the lasubine alkaloids Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland School of Physical and Mathematical Sciences Alkaloid Indolizidine Science::Chemistry::Organic chemistry Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine. EDB (Economic Devt. Board, S’pore) Accepted version 2019-10-03T08:30:41Z 2019-12-06T15:18:41Z 2019-10-03T08:30:41Z 2019-12-06T15:18:41Z 2018 Journal Article Nur Filza Mohamed Aslam, Simon, O., & Bates, R. W. (2018). Studies on the synthesis of the lasubine alkaloids. Tetrahedron, 74(38), 5032-5039. doi:10.1016/j.tet.2018.06.031 0040-4020 https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081 10.1016/j.tet.2018.06.031 en Tetrahedron © 2018 Elsevier. All rights reserved. This paper was published in Tetrahedron and is made available with permission of Elsevier. 8 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Alkaloid Indolizidine Science::Chemistry::Organic chemistry
spellingShingle	Alkaloid Indolizidine Science::Chemistry::Organic chemistry Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland Studies on the synthesis of the lasubine alkaloids
description	Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland
format	Article
author	Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland
author_sort	Simon, Oliver
title	Studies on the synthesis of the lasubine alkaloids
title_short	Studies on the synthesis of the lasubine alkaloids
title_full	Studies on the synthesis of the lasubine alkaloids
title_fullStr	Studies on the synthesis of the lasubine alkaloids
title_full_unstemmed	Studies on the synthesis of the lasubine alkaloids
title_sort	studies on the synthesis of the lasubine alkaloids
publishDate	2019
url	https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081
_version_	1759856662119710720

Studies on the synthesis of the lasubine alkaloids

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