Spinal cord organoids add an extra dimension to traditional motor neuron cultures

Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human....

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Main Authors:	Winanto, Khong, Zi-Jian, Hor, Jin-Hui, Ng, Shi-Yan
其他作者:	School of Biological Sciences
格式:	Article
語言:	English
出版:	2019
主題:	Spinal Cord Amyotrophic Lateral Sclerosis Science::Biological sciences
在線閱讀:	https://hdl.handle.net/10356/83527 http://hdl.handle.net/10220/49761
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id	sg-ntu-dr.10356-83527
record_format	dspace
spelling	sg-ntu-dr.10356-835272023-02-28T16:59:28Z Spinal cord organoids add an extra dimension to traditional motor neuron cultures Winanto Khong, Zi-Jian Hor, Jin-Hui Ng, Shi-Yan School of Biological Sciences Spinal Cord Amyotrophic Lateral Sclerosis Science::Biological sciences Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013). Published version 2019-08-23T04:19:30Z 2019-12-06T15:24:53Z 2019-08-23T04:19:30Z 2019-12-06T15:24:53Z 2019 Journal Article Winanto., Khong, Z.-J., Hor, J.-H., & Ng, S.-Y. (2019). Spinal cord organoids add an extra dimension to traditional motor neuron cultures. Neural Regeneration Research, 14(9), 1515-. doi:10.4103/1673-5374.255966 1673-5374 https://hdl.handle.net/10356/83527 http://hdl.handle.net/10220/49761 10.4103/1673-5374.255966 en Neural Regeneration Research © 2019 Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms 2 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Spinal Cord Amyotrophic Lateral Sclerosis Science::Biological sciences
spellingShingle	Spinal Cord Amyotrophic Lateral Sclerosis Science::Biological sciences Winanto Khong, Zi-Jian Hor, Jin-Hui Ng, Shi-Yan Spinal cord organoids add an extra dimension to traditional motor neuron cultures
description	Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).
author2	School of Biological Sciences
author_facet	School of Biological Sciences Winanto Khong, Zi-Jian Hor, Jin-Hui Ng, Shi-Yan
format	Article
author	Winanto Khong, Zi-Jian Hor, Jin-Hui Ng, Shi-Yan
author_sort	Winanto
title	Spinal cord organoids add an extra dimension to traditional motor neuron cultures
title_short	Spinal cord organoids add an extra dimension to traditional motor neuron cultures
title_full	Spinal cord organoids add an extra dimension to traditional motor neuron cultures
title_fullStr	Spinal cord organoids add an extra dimension to traditional motor neuron cultures
title_full_unstemmed	Spinal cord organoids add an extra dimension to traditional motor neuron cultures
title_sort	spinal cord organoids add an extra dimension to traditional motor neuron cultures
publishDate	2019
url	https://hdl.handle.net/10356/83527 http://hdl.handle.net/10220/49761
_version_	1759855389525934080

Spinal cord organoids add an extra dimension to traditional motor neuron cultures

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