Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism

• Main Authors: Petrlova, Jitka, Hansen, Finja C., van der Plas, Mariena J. A., Huber, Roland G., Mörgelin, Matthias, Malmsten, Martin, Bond, Peter J., Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Aggregation; Host defense peptides
• Online Access: https://hdl.handle.net/10356/83618; http://hdl.handle.net/10220/42778
• Institution: Nanyang Technological University

Effective control of endotoxins and bacteria is crucial for normal wound healing. During injury, the key enzyme thrombin is formed, leading to generation of fibrin. Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa thrombin-derived C-terminal peptides (TCPs), which bin...