Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure

• Main Authors: Kalailingam, Pazhanichamy, Tan, Kai Wei, Tan, Hui Bing, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Tan, Nguan Soon, Thanabalu, Thirumaran, Jain, Neeraj
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Actin; Skin models
• Online Access: https://hdl.handle.net/10356/83978; http://hdl.handle.net/10220/42834
• Institution: Nanyang Technological University

Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously, regulates actin polymerization and is essential during mouse development. We have previously shown that N-WASP is critical for cell-ECM adhesion in fibroblasts. To characterize the role of N-WASP in fibroblast for skin devel...