Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

• Main Authors: Drautz-Moses, Daniela Isabel, Schuster, Stephan Christoph, Kjelleberg, Staffan, Givskov, Michael, Yang, Liang, Chua, Song Lin, Ding, Yichen, Liu, Yang, Cai, Zhao, Zhou, Jianuan, Swarup, Sanjay
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Biofilms; c-di-GMP
• Online Access: https://hdl.handle.net/10356/84066; http://hdl.handle.net/10220/42927
• Institution: Nanyang Technological University

The host immune system offers a hostile environment with antimicrobials and reactive oxygen species (ROS) that are detrimental to bacterial pathogens, forcing them to adapt and evolve for survival. However, the contribution of oxidative stress to pathogen evolution remains elusive. Using an experime...