Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria

• Main Authors: Brussee, Janneke M., Lampah, Daniel A., Anstey, Nicholas M., Duffull, Stephen B., Yeo, Tsin Wen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: arginine; malaria falciparum
• Online Access: https://hdl.handle.net/10356/84697; http://hdl.handle.net/10220/41965
• Institution: Nanyang Technological University

Impaired organ perfusion in severe falciparum malaria arises from microvascular sequestration of parasitized cells and endothelial dysfunction. Endothelial dysfunction in malaria is secondary to impaired nitric oxide (NO) bioavailability, in part due to decreased plasma concentrations of L-arginine,...