Kinetic and cross-sectional studies on the genesis of hypoargininemia in severe pediatric plasmodium falciparum malaria

• Main Authors: Florence, Salvatore M., Kalingonji, Ayam R., Yeo, Tsin Wen, Lopansri, Bert K., Thompson, J. Will, Young, Sarah, Millington, David S., Weinberg, J. Brice, Granger, Donald L., Mwaikambo, Esther D., Matthew, P. Rubach, Zhang, Haoyue, Mukemba, Jackson P., Anstey, Nicholas M.
• Other Authors: Adams, John H.
• Format: Article
• Language: English
• Published: 2019
• Subjects: Arginine; DRNTU::Science::Medicine; Plasmodium Falciparum
• Online Access: https://hdl.handle.net/10356/85330; http://hdl.handle.net/10220/48465
• Institution: Nanyang Technological University

The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the plasma concentrations of amino acids involved i...