Kinetic and cross-sectional studies on the genesis of hypoargininemia in severe pediatric plasmodium falciparum malaria

• Main Authors: Florence, Salvatore M., Kalingonji, Ayam R., Yeo, Tsin Wen, Lopansri, Bert K., Thompson, J. Will, Young, Sarah, Millington, David S., Weinberg, J. Brice, Granger, Donald L., Mwaikambo, Esther D., Matthew, P. Rubach, Zhang, Haoyue, Mukemba, Jackson P., Anstey, Nicholas M.
• 其他作者: Adams, John H.
• 格式: Article
• 語言: English
• 出版: 2019
• 主題: Arginine; DRNTU::Science::Medicine; Plasmodium Falciparum
• 在線閱讀: https://hdl.handle.net/10356/85330; http://hdl.handle.net/10220/48465
• 機構: Nanyang Technological University

The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the plasma concentrations of amino acids involved i...