Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes

Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.

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Main Authors:	Lei, Chuanhu, Cao, Jiajia, Zhou, Jianrong Steve
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2017
Subjects:	Palladium catalysis Ketone
Online Access:	https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-85142
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spelling	sg-ntu-dr.10356-851422023-02-28T19:22:32Z Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve School of Physical and Mathematical Sciences Palladium catalysis Ketone Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes. MOE (Min. of Education, S’pore) Accepted version 2017-08-25T05:19:54Z 2019-12-06T15:58:00Z 2017-08-25T05:19:54Z 2019-12-06T15:58:00Z 2016 Journal Article Lei, C., Cao, J., & Zhou, J. S. (2016). Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes. Organic Letters, 18(23), 6120-6123. 1523-7060 https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631 10.1021/acs.orglett.6b03130 en Organic Letters © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Organic Letters, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.orglett.6b03130]. 5 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Palladium catalysis Ketone
spellingShingle	Palladium catalysis Ketone Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
description	Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve
format	Article
author	Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve
author_sort	Lei, Chuanhu
title	Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
title_short	Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
title_full	Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
title_fullStr	Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
title_full_unstemmed	Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
title_sort	palladium-catalyzed arylation of ketones and acetonitrile with ortho alkylation of aryl rings: de novo synthesis of tetralines and benzocycloheptenes
publishDate	2017
url	https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631
_version_	1759856697862520832

Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes

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