Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes

• Main Authors: Lei, Chuanhu, Cao, Jiajia, Zhou, Jianrong Steve
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Palladium catalysis; Ketone
• Online Access: https://hdl.handle.net/10356/85142; http://hdl.handle.net/10220/43631
• Institution: Nanyang Technological University

Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.