HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells

• Main Authors: Joanita Jasmen, Ng, Natasha Hui Jin, Lim, Chang Siang, Lau, Hwee Hui, Krishnan, Vidhya Gomathi, Kadiwala, Juned, Kulkarni, Rohit N., Ræder, Helge, Vallier, Ludovic, Hoon, Shawn, Teo, Adrian Kee Keong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences; Molecular Mechanism Of Gene Regulation; Diabetology
• Online Access: https://hdl.handle.net/10356/85706; http://hdl.handle.net/10220/49813
• Institution: Nanyang Technological University

Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development of foregut-derived liver and pancreatic cells through differentiation of human i...