Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

• Main Authors: Dai, Lingyun, Prabhu, Nayana, Diam, Go Ka, Sobota, Radoslaw, Larsson, Andreas, Nordlund, Pär, McCormick, Frank, Ghosh, Sujoy, Epstein, David M., Dymock, Brian W., Lee, Sang Hyun, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Shang, See Cheng, Minami, Noriaki, Sampetrean, Oltea, Saya, Hideyuki
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cancer-selective Lethality; Dual Inhibitory
• Online Access: https://hdl.handle.net/10356/87414; http://hdl.handle.net/10220/44426
• Institution: Nanyang Technological University

Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, we identify the PIP4K lipid kinases as the target...