Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, we identify the PIP4K lipid kinases as the target...
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/87414 http://hdl.handle.net/10220/44426 |
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Institution: | Nanyang Technological University |
Language: | English |
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