Productive entry of foot-and-mouth disease virus via macropinocytosis independent of phosphatidylinositol 3-kinase

• Main Authors: Han, Shi-Chong, Guo, Hui-Chen, Sun, Shi-Qi, Jin, Ye, Wei, Yan-Quan, Feng, Xia, Yao, Xue-Ping, Cao, Sui-Zhong, Xiang Liu, Ding, Liu, Xiang-Tao
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Virus Replication; DRNTU::Science::Biological sciences; Foot-and-Mouth Disease Virus
• 在線閱讀: https://hdl.handle.net/10356/87484; http://hdl.handle.net/10220/46731
• 機構: Nanyang Technological University

Virus entry is an attractive target for therapeutic intervention. Here, using a combination of electron microscopy, immunofluorescence assay, siRNA interference, specific pharmacological inhibitors, and dominant negative mutation, we demonstrated that the entry of foot-and-mouth disease virus (FMDV)...